meta content='nobel,nobel prize,a nobel prize winner,nobelprize ,nobel prize winners ,nobel prize 2010,nobel prize winners 2010,alfrid nobel ' name='keywords'/> Nobel Prize: Nobel Prize 2009 Elizabeth H. Blackburn : Papers published in refereed scientific journals

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Nobel Prize 2009 Elizabeth H. Blackburn : Papers published in refereed scientific journals


 1. Davidson, B.E., E.H. Blackburn and T.A.A. Dopheide. Chorismate mutase-prephenate dehydratase
from Escherichia coli K-12. I. Purification, molecular weight, and amino acid composition. J. Biol.
Chem. 241: 4441–4446 (1972).
2. Blackburn, E.H. and F.J. R. Hird. Metabolism of glutamine and glutamate by rat liver
mitochondria. Arch. Biochem. Biophys. 152: 258–264 (1972).
3. Blackburn, E.H., F.J.R. Hird and I.K. Jones. Metabolism of glutamine and ammonia in rat liver:
the effects of N-acetylglutamate and phosphate. Arch. Biochem. Biophys. 152: 265–271 (1972).
4. E.H. Blackburn. Transcription by Escherichia coli RNA polymerase of a single-stranded fragment
by bacteriophage 174 DNA 48 residues in length. J. Mol. Biol. 93: 367–374 (1975).
5. Air, G.A., E.H. Blackburn, F. Sanger and A.R. Coulson. The nucleotide and amino acid sequences
of the N (5') terminal region of gene G of bacteriophage X174. J. Mol. Biol. 96: 703–719 (1975).
6. E.H. Blackburn. Transcription and sequence analysis of a fragment of bacteriophage 174 DNA. J.
Mol. Biol. 107: 417–431 (1976).
7. Air, G.M., E.H. Blackburn, A.R. Coulson, F. Gailbert, F. Sanger, J.W. Sedat and E.B. Ziff. Gene
F. of bacteriophage X174. Correlation of nucleotide sequences from the DNA and amino acid
sequences from the gene product. J. Mol. Biol. 107: 445–458 (1976).
8. Blackburn, E.H. and J.C. Gall. A tandemly repeated sequence at the termini of the
extrachromosomal ribosomal RNA genes in Tetrahymena. J. Mol. Biol. 120: 33–53 (1978).
9. Pan, W.-C. and E.H. Blackburn. Single extrachromosomal ribosomal RNA gene copies are
synthesized during amplification of the rDNA in Tetrahymena. Cell 23: 459–466 (1981).
10. Blackburn, E.H. and S.-S. Chiou. Non-nucleosomal packaging of a tandemly repeated DNA
sequence at termini of extrachromosomal DNA coding for rRNA in Tetrahymena. Proc. Natl.
Acad. Sci. USA 78: 2263–2267 (1981).
11. Katzen, G.M., G.M. Cann and E.H. Blackburn. Sequence-specific fragmentation of macronuclear
DNA in a holotrichous ciliate. Cell 24: 313–320 (1981).
12. Yao, M.-C., E.H. Blackburn and J. Gall. Tandemly repeated C-C-C-C-A-A hexanucleotide of
Tetrahymena rDNA is present elsewhere in the genome and may be related to the alteration of the
somatic genome. J. Cell Biol. 90: 515–520 (1981).

13. Pan, W.-C., E. Orias, M. Flacks and E.H. Blackburn. Allele-specific, selective amplification of a
ribosomal RNA gene in Tetrahymena thermophila. Cell 28: 596–604 (1982).
14. Szostak, J.W. and E.H. Blackburn. Cloning yeast telomeres on linear plasmid vectors. Cell 29:
245–255 (1982).
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15. Blackburn, E.H., W.-C. Pan and C. Johnson. Methylation of ribosomal RNA genes in Tetrahymena
thermophila Nucl. Acids Res. 11: 5131–5145 (1983).
16. Blackburn, E.H. and P.B. Challoner. Identification of a telomeric DNA sequence in Trypanosoma
brucei. Cell 36: 447–457 (1984).
17. Shampay, J., J.W. Szostak and E.H. Blackburn. DNA sequences of telomeres maintained in yeast.
Nature 310 : 154–157 (1984).
18. Bruns, P., A.L. Katzen, L. Martin and E.H. Blackburn. A drug resistant mutation in the Ribosomal
DNA of Tetrahymena. Proc. Natl. Acad. Sci. USA 82: 2844–2846 (1985).
19. Spangler, E. and E.H. Blackburn. The nucleotide sequence of the 17S ribosomal RNA gene of
Tetrahymena thermophila and the identification of point mutations resulting in resistance to the
antibiotics Paromomycin and Hygromycin. J. Biol. Chem. 260: 6334–6340 (1985).
20. Howard, E.A. and E.H. Blackburn. Reproducible and variable genomic rearrangements occur in
the developing somatic nucleus of the ciliate Tetrahymena thermophila. Molec. Cell. Biol. 5:
2039–2050 (1985).
21. Challoner, P.B., A.A. Amin, R.E. Pearlman and E.H. Blackburn. Conserved arrangements of
repeated DNA sequences in the nontranscribed spacers of ciliate ribosomal RNA genes: Evidence
for molecular coevolution. Nucl. Acids Res. 13: 2661–2680 (1985).
22. Greider, C.W. and E.H. Blackburn. Identification of a specific telomere terminal transferase
activity in Tetrahymena extracts. Cell 43: 405–413 (1985).
23. Cherry, J.M. and E.H. Blackburn. The internally located telomeric sequences in the germline
chromosomes of Tetrahymena are at the conserved ends of a family of DNA elements. Cell 43:
747–758 (1985).
24. Budarf, M.L. and E.H. Blackburn. Chromatin structure of the telomeric region and 3'
nontranscribed spacer of Tetrahymena ribosomal RNA genes. J. Biol. Chem. 261: 363–369 (1986).
25. rCehpaelaltosn oefr ,c Pil.iBat.e a mnda cEr.oHn.u Bclleaacrk briubrons.o Cmoanls RerNvAat igoenn oef mseoqleuceunlceess. aNdujaccl.e Antc tiod st hRee tse. l1o4m: e6r2ic9 9C–46A321 1
(1986).

26. Larson D.D., E.H. Blackburn, P.C. Yaeger and E. Orias. Control of rDNA Replication in
Tetrahymena involves a cis-Acting Upstream Repeat of a Promoter Element. Cell 47: 229–240
(1986).
27. Budarf, M.L. and E.H. Blackburn. S1 Nuclease sensitivity of a double-stranded telomeric DNA
sequence. Nucl. Acids Res. 15: 6273–6292 (1987).
28. Larson, D.D., E.A. Spangler and E.H. Blackburn. Dynamics of telomere length variation in
Tetrahymena thermophila. Cell 50: 477–483 (1987).
29. Greider, C.W. and E.H. Blackburn. The telomere terminal transferase of Tetrahymena is a
ribonucleoprotein enzyme with two distinct primer specificity components. Cell 51: 887–898
(1987).
30. Henderson, E., C.C. Hardin, Steven K. Wolk, I. Tinoco, Jr. and E.H. Blackburn. Telomeric DNA
oligonucleotides form novel intramolecular structures containing guanine-guanine base parts. Cell
51: 899–908 (1987).
29
31. Forney, J., E.R. Henderson and E.H. Blackburn. Identification of the telomeric sequence of the
acellular slime molds Didyminum iridis and Physarum polycephalum. Nucl. Acids Res. 15: 9143–
9152 (1987).
32. Forney, J.D. and E.H. Blackburn. Developmentally controlled telomere addition in wild type and
mutant paramecia. Mol. Cell. Biol. 8: 251–258 (1988).
33. Shampay, J. and E.H. Blackburn. Generation of telomere length heterogeneity in S. cerevisiae.
Proc. Natl. Acad. Sci. USA 85: 534–538 (1988).
34. E. Orias, D. Larson, Y.-F. Hu, G.-L Yu, J. Karttunen, A. Løvlie, B. Haller and E.H. Blackburn.
Replacement of the macronuclear ribosomal RNA genes of a mutant Tetrahymena using
electroporation. Gene 70: 295–301 (1988).
35. Spangler, E.A., T. Ryan and E.H. Blackburn. Developmentally regulated telomere addition in
Tetrahymena thermophila . Nucl. Acids Res. 16: 5569–5585 (1988).
36. Yu, G.-L., M. Hasson and E.H. Blackburn. Circular ribosomal DNA plasmids transform
Tetrahymena thermophila by homologous recombination with endogenous macronuclear
ribosomal DNA. Proc. Natl. Acad. Sci. USA 85: 5151–5155 (1988).
37. Henderson, E.R. and E.H. Blackburn. An Overhanging 3' terminus is a conserved feature of
telomeres. Mol. Cell. Biol. 9: 345–348 (1989).
38. Greider, C.W. and E.H. Blackburn. A telomeric sequence in the RNA of Tetrahymena telomerase
required for telomere repeat synthesis. Nature 337: 331–337 (1989).
39. Yaeger, P.C., E. Orias, W.-L. Shaiu, D.D. Larson and E.H. Blackburn. The replication advantage
of a free linear rRNA gene is restored by somatic recombination in Tetrahymena thermophila.
Mol. Cell. Biol. 9: 452–460 (1989).
40. Shippen-Lentz, D. and E. H. Blackburn. Telomere terminal transferase activity from Euplotes
crassus adds large numbers of TTTTGGGG repeats onto telomeric primers. Mol. Cell. Biol. 9:
2761–2764 (1989).
41. Shampay, J. and E.H Blackburn. Tetrahymena micronuclear sequences that function as telomeres
in yeast. Nucl. Acids Res. 17: 3247–3260 (1989).
42. Phan, H.L., J. Forney and E.H. Blackburn. Analysis of Paramecium macronuclear DNA using
pulsed field gel electrophoresis. J. Protozoology 36: 402–408 (1989).
43. Robinson, E.K., P.D. Cohen and E.H. Blackburn. A novel DNA deletion-ligation reaction
catalyzed in vitro by a developmentally controlled activity from Tetrahymena cells. Cell 58: 887–
900 (1989).
44. Yu, G.-L. and E.H. Blackburn. Transformation of Tetrahymena thermophila with a mutated
circular ribosomal DNA plasmid vector. Proc. Natl. Acad. Sci. USA 86: 8487–8491 (1989).
45. Blackburn, E.H., C.W. Greider, E. Henderson, M.S. Lee, J. Shampay, and D.-Shippen-Lentz.
Recognition and elongation of telomeres by telomerase. Genome 31: 553–560 (1989).
46. Shippen-Lentz, D. and E. H. Blackburn. Functional evidence for an RNA template in telomerase.
Science 247: 546–552 (1990).
47. Yu, G.-L., J.D. Bradley, L.D. Attardi and E.H. Blackburn. In vivo alteration of telomere sequences
30
and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 344: 126–132 (1990).
48. Blackburn, E.H. and V. Lundblad. RNA-dependent polymerase motifs in the EST1 protein:
tentative identification of a component of an essential yeast telomerase. Cell 60: 529–530 (1990).
49. Yu, G.-L. and E.H. Blackburn. Amplification of tandemly repeated origin control sequences
confers a replication advantage on rDNA replicons in Tetrahymena thermophila. Mol. Cell. Biol.
10: 2070–2080 (1990).
50. Romero, D. and E.H. Blackburn. A conserved secondary structure for telomerase RNA. Cell 67:
343–353 (1991).

51. Yu, G-L. and E.H. Blackburn. Developmentally programmed chromosome healing by telomerase
in Tetrahymena. Cell 67: 823–832 (1991).
52. Wyman, C. and E.H. Blackburn. Tel-1 transposon-like elements of Tetrahymena thermophila are
associated with micronuclear genome rearrangements. Genetics 128: 57–67 (1991).
53. Lundblad, V. and E.H. Blackburn. An alternate pathway for yeast telomere maintenance rescues
est1- senescence. Cell 73: 347–360 (1993).
54. Lee, M. and E.H. Blackburn. Sequence-specific DNA primer effects on telomerase polymerization
activity. Mol. Cell. Biol. 13: 6586–6599 (1993).
55. Shippen, D.E., E.H. Blackburn and C.M. Price. DNA bound by the Oxytricha telomere protein is
accessible to telomerase and other DNA polymerases. Proc. Natl. Acad. Sci. USA 91: 405–409
(1994).
56. Kapler, G.M. and E.H. Blackburn. A weak germline excision mutation blocks developmentallycontrolled
amplification of the rDNA minichromosome of Tetrahymena thermophila. Genes Dev.
8: 84–95 (1994).
57. Gilley, D. and E.H. Blackburn. Lack of telomere shortening during senescence in Paramecium.
Proc. Natl. Acad. Sci. USA 91: 1955–1958 (1994).
58. McEachern, M.J. and E.H. Blackburn. A conserved sequence motif within the exceptionally
diverse telomeric sequenced of budding yeasts. Proc. Natl. Acad. Sci. USA 91: 3453–3457.
(1994).
59. Kapler, G.M., E. Orias and E.H. Blackburn. Tetrahymena thermophila mutants defective in the
developmentally programmed maturation and maintenance of the rDNA minichromosome.
Genetics 137: 455–466 (1994).
60. Strahl, C. and E.H. Blackburn. The effects of nucleotide analogs on telomerase and telomeres in
Tetrahymena. Nuc. Acids Res. 22: 893–900. (1994)
61. Bhattacharyya, A. and E.H. Blackburn. Architecture of telomerase RNA. EMBO J. 13: 5721–5731
(1994).
62. Kirk, K., and E.H. Blackburn. An unusual sequence arrangement in the telomeres of the germ-line
micronucleus in Tetrahymena thermophila. Genes Dev. 9: 59–71 (1995).
63. Romero, D.P. and E.H. Blackburn. Circular rDNA replicons persist in Tetrahymena thermophila
transformants synthesizing GGGGTC telomeric repeats. J. Eukaryotic Micro. 42: 32–43 (1995).
31
64. Pan, W-J. and E.H. Blackburn. Tandem Repeats of the 5' Non-transcribed Spacer of Tetrahymena
rDNA Function as high copy number autonomous replicons in the macronucleus but do not
prevent rRNA gene dosage regulation. Nuc. Acids Res. 23: 1561–1569. (1995).
65. Pan, W-J., R.C. Gallagher and E.H. Blackburn. Replication of an rDNA origin plasmid in the
Tetrahymena macronucleus is prevented by transcription through the origin from an RNA
polymerase I promoter. Mol. Cell. Biol. 15: 3372–3381 (1995).
66. Cohn, M., and E.H. Blackburn. Telomerase in yeast. Science 269: 396–400 (1995).
67. McEachern, M.J. and E.H. Blackburn. Runaway telomere elongation caused by telomerase RNA
mutations. Nature 376: 403–409 (1995).
68. Gilley, D., M.S. Lee and E.H. Blackburn. Altering specific telomerase RNA template residues
affects active site function. Genes Dev. 9: 2214–2226 (1995).
69. Strahl, C. and E.H. Blackburn. Effects of reverse transcriptase inhibitors on telomere length and
telomerase activity in two immortalized human cell lines. Mol. Cell. Biol. 16: 53–65 (1996).
70. Gilley, D. and E.H. Blackburn. Specific RNA residue interactions required for enzymatic functions
of Tetrahymena Telomerase. Mol. Cell. Biol. 16: 66–75 (1996).
71. McEachern, M.J. and E.H. Blackburn. Cap-prevented recombination between terminal telomeric
repeat arrays (telomere CPR) maintains telomeres in K lactis lacking telomerase. Genes Dev. 10:
1822–1834 (1996).
72. Krauskopf, A. and E.H. Blackburn. Control of telomere growth by interactions of RAP1 with the
most distal telomeric repeats. Nature 383: 354–357 (1996).
73. Prescott, J. and E.H. Blackburn. Telomerase RNA mutations in Saccharomyces cerevisiae alter
telomerase action and reveal non-processivity in vivo and in vitro. Genes Dev. 11:528–540 (1997).
74. Wang H. and E.H. Blackburn. De novo telomere addition by Tetrahymena telomerase in vitro.
EMBO J. 16:866–879 (1997).
75. Kirk, K.E., B.P. Harmon, I.K. Reichardt, J.W. Sedat and E.H. Blackburn. Block in anaphase
chromosome separation caused by a telomerase template mutation. Science 275:1478–1481
(1997).

76. Bhattacharyya, A. and E.H. Blackburn. Aspergillus nidulans maintains short telomeres throughout
development. Nuc. Acids Res. 25:1426–1431 (1997).
77. Bhattacharyya, A. and E.H. Blackburn. A functional telomerase RNA swap in vivo reveals the
importance of non-template RNA domains. Proc. Natl. Acad. USA 94:2823–2827 (1997).
78. Prescott, J. and E.H. Blackburn. Functionally interacting telomerase RNAs in the yeast telomerase
complex. Genes Dev. 11:2790–2800 (1997).
79. Wang, H., D. Gilley and E.H. Blackburn. A novel specificity for the primer-template pairing
requirement in Tetrahymena telomerase. EMBO J. 17:1152–1160 (1998).
80. Cohn, M., M.J. McEachern and E.H. Blackburn. Telomeric sequence diversity within the genus
Saccharomyces. Curr. Genetics 33:83–91 (1998).
81. Gallagher, R.C. and E.H. Blackburn. A promoter region mutation affecting replication of the
Tetrahymena rDNA minichromosome. Mol. Cell. Biol. 18:3021–3033 (1998).
32
82. Frenck, R.W., Blackburn, E.H. and K.M. Shannon. The rate of telomere sequence loss in human
leukocytes varies with age. Proc. Natl. Acad. Sci. USA, 95:5607–5610 (1998).
83. Cohen, P.D. and E.H. Blackburn. Two types of telomeric chromatin in Tetrahymena thermophila.
J. Mol. Biol. 280:327–344 (1998).
84. Fulton, T.B. and E.H. Blackburn. Identification of Kluyveromyces lactis telomerase: discontinuous
synthesis along the thirty nucleotide-long templating domain. Mol. Cell. Biol 18(9):4961–70
(1998).
85. Krauskopf, A. and E.H. Blackburn. Rap1 Protein Regulates Telomere Turnover in Yeast. Proc.
Natl. Acad. Sci. USA. 95(21):12486–91 (1998).
86. Roy, J., Boswell Fulton, T. and E. H. Blackburn. Specific telomerase RNA residues distant from
the template are essential for telomerase function. Genes Dev. 12(20): 3286–3300 (1998).
87. Cano, M. I., J. Dungan, N. Agabian, and E. H. Blackburn. Telomerase in Kinetoplastid Parasitic
Protozoa. Proc. Natl. Acad. Sci. USA. 96: 3616–3621 (1999).
88. Zhu, J., H. Wang, J. M. Bishop, and E. H. Blackburn. Telomerase extends the lifespan of virustransformed
human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA. 96: 3723–
3728 (1999).
89. Smith, C.D. and E.H. Blackburn. Uncapping and deregulation of telomeres lead to detrimental
cellular consequences in yeast. Journal of Cell Biology 145(2): 203–214 (1999).
90. Gilley, D. and E.H. Blackburn. The telomerase RNA pseudoknot is critical for the stable assembly
of the catalytically active ribonucleoprotein. Proc. Natl. Acad. Sci. USA. 96: 6621–6625 (1999).
91. Hsu, H.-L., D. Gilley, E.H. Blackburn, and D.J. Chen. Ku is associated with the telomere in
mammals. Proc. Natl. Acad. Sci. USA. 96: 12454–12458 (1999).
92. Prescott, J. and E.H. Blackburn. Telomerase RNA Template Mutations Reveal Sequence-Specific
Requirements for the Activation and Repression of Telomerase Action at Telomeres. Mol. Cell.
Biol. 20: 2941-2948 (2000).
93. Tzfati, Y., T.B. Fulton, J. Roy, and E.H. Blackburn. Template boundary in a yeast telomerase
specified by RNA structure. Science. 288(5467):863-7 (2000).
94. Ware T.L., H. Wang, and E.H. Blackburn. Three telomerases with completely non-telomeric
template replacements are catalytically active. EMBO Journal 19(12): 3119-3131 (2000).
95. McEachern, M.J., S. Iyer, T.B. Fulton, and E.H. Blackburn. Telomere fusions caused by mutating
the terminal region of telomeric DNA. Proc. Natl. Acad. Sci. USA. 97: 11409-11414 (2000).
96. Kim. M.M., M.A. Rivera, I.L. Botchkina, R. Shalaby, A.D. Thor, and E.H. Blackburn. A low
threshold level of expression of mutant-template telomerase RNA is sufficient to inhibit human
tumor cell growth. Proc. Natl. Acad. Sci. U.S.A. 98:7982-7987 (2001).
97. Chan, S. J. Chang, J. Prescott, and E.H. Blackburn. Altering telomere structure allows telomerase
to act in yeast lacking ATM kinases. Current Biology 11: 1240-1250 (2001).
98. Nautiyal, S., J. DeRisi, and E.H. Blackburn. A genome-wide gene-expression response to
telomerase deletion mutant of S. cerevisiae. Proc. Natl. Acad Sci. U.S.A. 99 (14):9316-21 (2002).
33
99. McEachern, M.J., D.H. Underwood and E.H. Blackburn. Dynamics of telomeric DNA turnover in
yeast. Genetics 160: 63–73 (2002).
100. Cano, M.I.N., J.J. Blake, E.H. Blackburn, and N. Agabian A trypanosoma brucei protein complex

that binds G-overhangs and co-purifies with telomerase activity. J. Biol. Chem. 277:896-906
(2002).
101. Seto, A.G., A.J. Livengood, Y. Tzfati, E.H. Blackburn, and T.R. Cech. A bulged stem tethers
Est1p to telomerase RNA in budding yeasts. Genes Dev. 16: 2800-2812 (2002).
102. Comolli, L.R., I. Smirnov, L. Xu, E.H. Blackburn and T.L. James. A molecular switch underlies a
human telomerase disease. Proc. Natl. Acad Sci. U.S.A. 99: 16998-17003(2002).
103. Smith, C.D., D.L. Smith, J.L. DeRisi and E.H. Blackburn. Telomeric protein distributions and
remodeling through the cell cycle in S. cerevisiae. Mol. Biol. Cell 14: 556-570 (2003). (First
published online in MBC in Press, December 7 2002).
104. Ly, H., L. Xu, M. Rivera, T.G. Parslow and E.H. Blackburn. A role for a novel ‘trans-pseudoknot’
RNA-RNA interaction in the functional dimerization of human telomerase. Genes Dev 17: 1078-
1083 (2003).
105. Chan, S. and E.H. Blackburn. Telomerase and ATM/Tel1p protect telomeres from nonhomologous
end joining. Molec Cell 11:1379-1387 (2003).
106. Tzfati, Y., Knight, Z., Roy, J. and E.H. Blackburn. A novel pseudoknot element is essential for the
action of a yeast telomerase. Genes Dev 17:1779-1788 (2003).
107. Kim, M.M, L. Xu and E. H. Blackburn. Catalytically normal human telomerase mutants with
allele-specific biological properties. Exper Cell Res 288: 277-287 (2003).
108. Ly, H., Blackburn, E.H. and Parslow, T.G. Comprehensive structure-function analysis of the core
domain of human telomerase RNA. Mol Cell Biol 23: 6849-6856 (2003).
109. Seto, A.G., K. Umansky, Y. Tzfati, A.J. Zaug, E.H. Blackburn, and T.R. Cech. A templateproximal
RNA paired element contributes to S. cerevisiae telomerase activity. RNA. 9:1323-1332
(2003).
110. Lin, J., D.L. Smith and E.H. Blackburn. Mutant telomere sequences lead to impaired chromosome
separation and a unique checkpoint response. Molec. Biol. Cell 15: 1623-1634 (2004) (Published
online before print in MBC in Press, January 23, 2004).
111. Lin, J. and E.H. Blackburn. Nucleolar protein PinX1p regulates telomerase by sequestering its
protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes Dev. 18: 387-396
(2004) (Published online before print, Feb. 20, 2004).
112. Makovets, S., I. Herskowitz and E.H. Blackburn. Anatomy and dynamics of DNA replication fork
movement in yeast telomeric regions. Mol. Cell. Biol. 24: 4019-4031 (2004).
113. Li, S., J.E. Rosenberg, A.A. Donjacour, I.L. Botchkina, Y.-K. Hom, G.R. Cunha and E.H.
Blackburn. Rapid inhibition of cancer cell growth induced by lentiviral expression of mutanttemplate
telomerase RNA constructs and anti-telomerase siRNA. Cancer Res 64: 4833-4840
(2004).
114. Nosrati, M. S. Li, S. Bagheri, D. Ginzinger, E.H. Blackburn, R.J. Debs, and M. Kashani-Sabet.
Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA. Clin
34
Cancer Res. 10:4983-4990 (2004).
115. Lin, J., H. Ly, A. Hussain, M. Abraham, S. Pearl, T.G. Parslow, Y. Tzfati and E.H. Blackburn. A
universal telomerase RNA core structure includes structure motifs required for binding the
telomerase reverse transcriptase protein. Proc. Natl. Acad. Sci. USA 101:14713-8 (2004).
116. Levy, D.L. and E.H. Blackburn. Counting of Rif1p and Rif2p on Saccharomyces cerevisiae
telomeres regulates telomere length. Mol. Cell. Biol. 24: 10857-10867 (2004).
117. Epel, E.S., E.H. Blackburn, J. Lin, F. Dhabar, N. Adler, J. Morrow, and R. Cawthon. Accelerated
telomere shortening in response to life stress. Proc Natl Acad Sci USA. 101: 17312-15 (2004).
118. Rivera, M.A. and E.H. Blackburn. Processive utilization of the human telomerase template: Lack
of a requirement for template switching. J Biol Chem 279: 53770-53781 (2004).
119. Xu, L. and E.H. Blackburn. Human Rif1 protein binds aberrant telomeres and aligns along
anaphase midzone microtubules. J Cell Biol 167: 819-830 (2004).
120. Li, S., J. Crothers, C.M. Haqq and E.H. Blackburn. Cellular and gene expression responses
involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated
depletion of telomerase RNA. J. Biol. Chem. 280:23709-23717 (2005).
121. Ly, H., M. Schertzer, W. Jastaniah, J. Davis, S.-L. Yong, Q. Ouyang, E.H. Blackburn, T.G.
Parslow and P.M Lansdorp. Identification and functional characterization of 2 variant alleles of the
telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita Blood 106: 1246-
1252 (2005). (Online May 10, 2005 [Epub ahead of print]).
122. Epel, E.S., J. Lin, F.H. Wilhelm, O.M. Wolkowitz, R. Cawthon, N. Adler, C. Dolbier, W.B.
Mendes, and E.H. Blackburn. Cell aging in relation to stress arousal and cardiovascular disease
risk factors. Psychoneuroendocrinology 31: 277-287 (2006) [Epub: Nov. 17, 2005].
123. Goldkorn, A. and E.H. Blackburn. Assembly of mutant template telomerase RNA into catalytically
active telomerase ribonucleoprotein at the telomere is required for apoptosis and cell cycle arrest in
human cancer cells. Cancer Research 66 (11):5763-71 (2006).
124. Bagheri S., Nosrati M., Li S., Fong S., Torabian S., Rangel J., Moore D.H., Feerman S., Laposa
R.R., Baehner F.L., Sagebiel R.W., Cleaver J.E. Haqq C., Debs R.J. Blackburn E.H. and Kashani-
Sabet M. Genes and pathways downstream of telomerase in melanoma metastasis. Proc. Natl.
Acad. Sci. USA 103: 11306-11311 (2006).
125. Min Hsu, Michael J. McEachern, Alain T. Dandjinou, Yehuda Tzfati, Erica Orr, Elizabeth H.
Blackburn, and Neal F. Lue Telomerase core components protect Candida telomeres from
aberrant overhang accumulation, PNAS, 104(28):11682-7. Epub 2007 Jul 3. PMCID:
PMC1913905
126. Njajou OT, Cawthon RM, Damcott CM, Wu S-H, Ott S, Garant MJ, Blackburn EH, Mitchell BD,
Shuldiner AR, Hsueh W-C. Telomere length is paternally inherited and is associated with parental
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