meta content='nobel,nobel prize,a nobel prize winner,nobelprize ,nobel prize winners ,nobel prize 2010,nobel prize winners 2010,alfrid nobel ' name='keywords'/> Nobel Prize: Nobel Prize 2009 in Physiology or Medicine (Jack Szostak " 3 ")

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Nobel Prize 2009 in Physiology or Medicine (Jack Szostak " 3 ")

Szostak in Ottawa, 1963, showing Jack Szostak, his father (Bill Szostak), and sisters Carolyn and Kathy, with the Canadian Parliament Buildings in the background

Jack Szostak 
Jack Szostak was born November 9, 1952 and grew up in Montreal and Ottawa. Although Szostak does not speak Polish, he stated in an interview with Wprost weekly that he remembers his Polish roots He attended Riverdale High School (Quebec) and graduated at the age of 15 with the scholars prize.
Jack Szostak  was only nineteen when he was awarded his B.S. in cell biology at McGill University in Montreal, Canada. He obtained his PhD in biochemistry at Cornell University (Ithaca, New York, USA), where he worked as a research assistant until 1979. He then moved to Harvard Medical School, where he has been a professor with the Department of Genetics since 1988. 
In 1988 too, he accepted an appointment with the Department of Molecular Biology at Boston's Massachusetts General Hospital, where he became an Alex Rich Distinguished Investigator in 2000. In 1998, Szostak became an Investigator at the Howard Hughes Medical Institute at Massachusetts General Hospital.

Jack Szostak is a biologist and Professor of Genetics at Harvard Medical School and Alexander Rich Distinguished Investigator at Massachusetts General Hospital, Boston

Jack Szostak Awards
* Nobel Prize 
  in Physiology or Medicine 2009
* National Academy of Sciences Award in Molecular Biology
* Hans Sigrist Prize, University of Bern, Switzerland
 * Genetics Society of America Medal
 2008 H.P. Heineken Prize for Biochemistry and Biophysics, Royal Netherlands Academy of Arts and Sciences  for his highly original insights into the fundamental processes of life
* The 2006 Lasker Award
Jack Szostak Education
 * Ph.D., biochemistry, Cornell University
•    B.S., cell biology, McGill University, Montreal, Canada

Jack Szostak publications

Doudna JA, Cormack BP, Szostak JW. Genetic Dissection of an RNA Enzyme. Cold Spring Harbor Symposia, Vol. LII. 1987
Michel F, Hanna M, Green R, Bartel DB, Szostak JW. Miniribozymes, Small Derivatives of the sunY Intron, Are Catalytically Active. Mol. Cell. Biol. 1989; 9: 5480-5483.
Doudna JA, Szostak JW. Stereochemical Course of Catalysis by the Tetrahymena Ribozyme. Science, 1989; 244: 692-694.
Doudna JA, Szostak JW, Rich A, Usman N. Chemical Synthesis of Oligoribonucleotides Containing 2-Aminopurine: Substrates for the Investigation of Ribozyme Function. J. Org. Chem. 1990; 55: 5547-5549.
Couture S, Ellington AD, Gerber AS, Cherry JM, Doudna JA, Green R, Hanna M, Pace U, Rajogopal J, Szostak JW. Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns. Nature, 1990; 347: 578-580.
Ellington AE, Szostak JW. In vitro Selection of RNA Molecules that Bind Specific Ligands. Nature, 1990; 346: 818-822.
Green R, Szostak JW, Benner SA, Rich A, Usman N. Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice-site of the Tetrahymena group I intron.Nuc. Acids Res., 1991; 19: 4161-4166.
Bartel DP, Zapp M, Green M, Szostak JW. HIV-1 Rev Regulation Involves Recognition of Non-Watson-Crick Base-pairs in Viral RNA . Cell, 1991; 67: 529-536.
Green R, Ellington AD, Bartel DP, Szostak JW. In Vitro Genetic Analysis: Selection and Amplification of Rare Functional Nucleic Acids. Methods: A Companion to Methods in Enzymol., 1991; 2: 75-86.
Bartel DP, Szostak JW. Template-Directed Primer Extension Catalyzed by the Tetrahymena Ribozyme. Mol. Cell. Biol. 1991; 11: 3390-3394.
Doudna JA, Couture S, Szostak JW. A multi-subunit ribozyme that is a catalyst of and a template for complementary strand RNA synthesis. Science 1991; 251: 1605-1608.

Green R and Szostak JW. Selection of a Ribozyme that Functions as a Superior Template in a Self-Copying Reaction. Science 1992; 258:1910-1915. .
Wilson CL, Szostak JW. Ribozyme Catalysis. Curr. Opin. in Struct. Biol. 1992; 2:749-756.
Famulok M, Szostak JW. In Vitro Selection of Specific Ligand Binding Nucleic Acids. Angew. Chem. Int. Ed. Engl. 1992; 31: 979-988.
Famulok M, Szostak JW. Stereospecific Recognition of Tryptophan Agarose by in Vitro Selected RNA. J. Am. Chem. Soc. 1992; 114: 3990-3991.
Szostak JW. In Vitro Genetics. Trends in Biochem. Sci. 1992; 17: 89-93.
Ellington AE, Szostak JW. Selection in vitro of single-stranded DNA molecules that fold into specific ligand binding structures. Nature 1992; 355:850-852.
Bartel DP, Szostak JW. Isolation of a new ribozymes from a large pool of random sequences. Science 1993; 261:1411-1418. .
Sassanfar M, Szostak JW. An RNA motif that binds ATP. Nature 1993; 364: 550-553.
Famulok M, Szostak JW. Selection of Functional RNA and DNA Molecules from Randomized Sequences. pp. 271-284, in Nucleic Acids and Molecular Biology, ed. F. Eckstein and D.M.J. Lilley, Springer-Verlag, 1993.
Szostak, J.W. and Ellington, A.E. In Vitro Selection of Functional RNA Sequences. pp. 511-533 in "The RNA World", ed. R. Gesteland and J. Atkins; Cold Spring Harbor Press, 1993.
Doudna JA, Szostak JW. Triplet extension: a novel strategy for RNA catalysed RNA replication. Biochemistry 1993; 32:2111-2115.

Bartel DP, Szostak JW. Study of RNA-protein recognition by in vitro selection. in RNA- Protein Interactions, eds. K. Nagai and I.W. Mattaj, Oxford University Press 1994.
Hanna M, Szostak JW. Suppression of mutations in the core of the Tetrahymena ribozyme by spermidine, ethanol and by substrate stabilization. Nuc. Acids Res. 1994; 22: 5326-5331.
Lorsch JR, Szostak JW. In vitro evolution of new ribozymes with polynucleotide kinase activity. Nature 1994; 371:31-36.
Chapman KB, Szostak JW. In Vitro Selection of Catalytic RNAs. Current Opinions in Structural Biology 1994; 4:618-622.
Green R, Szostak JW. Template-directed oligonucleotide assembly reactions catalyzed by a minimally structured ribozyme derived from a group I intron. pp. 277-283 in, Structural Biology: The State of the Art, Proceedings of the Eighth Conversation, State University of New York, Albany, NY 1993 Eds. Ramaswamy H. Sarma and Mukti H. Sarma, Adenine Press 1994
Peterson RD, Bartel DP, Szostak JW, Horvath SJ, Feigon J. H NMR Studies of the High- Affinity Rev Binding Site of the Rev Responsive Element of HIV-1 mRNA: Base Pairing in the Core Binding Element. Biochemistry 1994; 33: 5357-5366.
Lorsch J, Szostak, JW. In Vitro Selection of RNA Aptamers Specific for Cyanocobalamin. Biochemistry 1994; 33:973-982.
Lin, C-W, Szostak JW. Evidence That the Guanosine Substrate of the Tetrahymena Ribozyme is Bound in the Anti Conformation and That N7 Contributes to Binding. Biochemistry 1994; 33:2703-2707.
Green R, Szostak JW. In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron. J. Mol. Biol. 1994; 235:140-155

Lorsch JR, Bartel DP, Szostak JW. Reverse transcriptase reads through a 2'-5' linkage and a 2'-thiophosphate in a template. Nuc. Acids Res. 1995; 23: 2811-2814.
Ekland EH, Szostak JW, Bartel DP. Structurally complex and highly active RNA ligases derived from random RNA sequences. Science 1995; 269: 364-370. .
Cuenod B, Szostak JW. A DNA metalloenzyme with DNA ligase activity. Nature 1995; 375: 611-614.
Chapman KB, Szostak JW. Isolation of a ribozyme with 5'-5' ligase activity. Chemistry and Biology 1995; 2: 325-333.
Wilson CW, Szostak JW. In vitro evolution of a self-alkylating ribozyme. Nature 1995; 374: 777-782.
Whoriskey S, Usman N, Szostak JW. Total chemical synthesis of a ribozyme derived from a group I intron. Proc. Natl. Acad. Sci. U.S.A. 1995; 92: 2465-2469.
Lauhon CT, Szostak JW. RNA Aptamers that bind Flavin and Nicotinamide Redox Cofactors. J. Am. Chem. Soc. 1995; 117: 1246-1257. .
Huizenga DE, Szostak JW. DNA Aptamer that Binds Adenosine and ATP. Biochemistry 1995; 34: 656-665.
Hager AJ, Pollard JD, Szostak JW. Ribozymes: aiming at RNA replication and translation. Chem. Biol. 1996; 3:717-725.
Huang Z, Szostak JW. 3' End-Labeling of RNA with DNA Polymerase. Nuc. Acids Res. 1996; 24: 4360-4361. .
Lohse P, Szostak JW. Ribozyme-catalysed amino acid transfer reactions. Nature 1996; 381: 442-444.
Rohatgi R, Bartel D, Szostak JW. Non-enzymatic, Template-Directed Ligation of Oligoribonucleotides is Highly Regioselective for the Formation of 3'-5' Phosphodiester Bonds. J. Am. Chem. Soc. 1996; 118: 3340-3334. .
Rohatgi R, Bartel D, Szostak JW. Kinetic and Mechanistic Analysis of Nonenzymatic, Template-Directed Oligonucleotide Ligation. J. Am. Chem. Soc. 1996; 118: 3332-3339 .
Lorsch JR, Szostak JW. Chance and Necessity in the Selection of Nucleic Acid Catalysts. Accounts Chem. Res. 1996; 29: 103-110. .
Lorsch JR, Szostak JW. In Vitro Selection of Nucleic Acid Sequences that Bind Small Molecules. 1996. Chpt. 4 in Combinatorial Libraries: Synthesis, Screening and Application Potential. Ed. R. Cortese. Publ. Walter de Gruyter, Berlin, New York.

Roberts RW, Szostak JW. RNA-peptide fusions for the in Vitro selection of peptides and proteins. Proc. Natl. Acad. Sci. USA 1997; 94: 12297-12302. .
Hager AJ, Szostak JW. Isolation of Novel Ribozymes that Ligate AMP-Activated RNA Substrates. Chem. Biol. 1997; 4:607-617.
Dieckmann T, Butcher SE, Sassanfar M, Szostak JW and Feigon J. Mutant ATP-Binding RNA aptamers reveal the structural basis for ligand binding. J. Mol. Biol. 1997; 273: 467- 478. .
Szostak JW. Introduction: Combinatorial Chemistry. Chem. Rev. 1997; 97 (2): 347-348, in: Chemical Reviews: Combinatorial Chemistry, a Thematic Issue, Guest Editor Jack W. Szostak.
Szostak JW. In Vitro Selection and Directed Evolution. 1998 Harvey Lecture Series. 1997-98;93:95-118. Review.
Holeman LA, Robinson SL, Szostak JW and Wilson C. Isolation and characterization of fluorophore-binding RNA aptamers. Folding & Design, 1998; 3:423-431.
Wilson C, Szostak JW. Isolation of a fluorophore-specific DNA aptamer with weak redox activity. Chem. Biol., 1998; 5: 609-617.
Wilson C, Nix J, Szostak JW. Functional requirements for specific ligand recognition by a biotin-binding RNA pseudoknot. Biochemistry 1998; 37:14410-9. .
Suga H, Cowan JA, Szostak JW. Unusual metal ion catalysis in an acyl transferase ribozyme. Biochemistry 1998; 37:10118-10125. .
Suga H, Lohse P, Szostak JW. Structural and Kinetic Characterization of an Acyl Transferase Ribozyme. J. Am. Chem. Soc. 1998; 120: 1151-1156.
Wilson DW, Szostak JW. In vitro Selection of Functional Nucleic Acids. Ann. Rev. Biochem., 1999; 68:611-648. .

Cho, G, Keefe, AD, Wilson, DS, Liu, R and Szostak, JW. Constructing high complexity synthetic libraries of long ORFs using in vitro selection. J.Mol.Biol. 2000; 297:309-319 .
Vaish NK, Fraley AW, Szostak JW, McLaughlin LW. Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids. Nucleic Acids Res. 2000 Sep 1;28(17):3316-22. .
Lee N, Bessho Y, Wei K, Szostak JW, Suga H. Ribozyme-catalyzed tRNA aminoacylation. Nat Struct Biol. 2000 Jan;7(1):28-33. .
Burgstaller P, Hale S, Sun L, Roberts RW, Szostak JW, Wagner R. Identification of epitope-like consensus motifs using mRNA display. J Mol Recognit. 2002 May-Jun;15(3):126-34.
Szostak JW. Constraints on the sizes of the earliest cells. In, 'Size Limits of Very Small Microorganisms', Proceedings of a Workshop of the Space Studies Board, National Research Council. 1999, National Academy Press.
Liu R, Barrick JE, Szostak JW, Roberts RW. Optimized synthesis of RNA-protein fusions for in vitro protein selection. Methods Enzymol. 2000;318:268-93.
Salehi-Ashtiani K, Szostak JW. In vitro evolution suggests multiple origins for the hammerhead ribozyme. Nature. 2001 Nov 1;414(6859):82-4. Szostak JW, Bartel, DP and Luisi, PL. Synthesizing Life. Nature. 2001; 409: 387-390. .
Keefe AD, Szostak JW. Functional proteins from a random-sequence library. Nature. 2001 Apr 5;410(6829):715-8. .
Keefe AD, Wilson, DS, Seelig, B, and Szostak JW. One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag. Protein Expression and Purification. 2001; 28 : 440-446. .
Wilson DS, Keefe AD, Szostak JW.The use of mRNA display to select high-affinity protein-binding peptides. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3750-5.

Davis, JH, Szostak, JW. Isolation of high-affinity GTP aptamers from partially structured RNA libraries. Proc Natl Acad Sci U S A. 2002 Sep 3; 99(18):11616-11621. .
Hanczyc, MM, Fujikawa, SM, Szostak, JW. Experimental models of primitive cellular compartments: encapsulation, growth, and division. Science. 2003 Oct 24; 302: 618-622. .
Chaput, JC, Szostak, JW. TNA synthesis by DNA polymerases. J Am Chem Soc. 2003 Aug 6;125(31):9274-5. .
Vaish, NK, Larralde, R. Fraley, AW, Szostak, JW, McLaughlin, LW. A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality. Biochemistry. 2003 Jul 29;42(29):8842-51. .
Szostak, JW. Functional information: molecular messages. Nature. 2003 June 12; 423: 689. .
Huang, Z, and Szostak, JW. Selective labeling and detection of specific RNAs in an RNA mixture. Anal Biochem. 2003 Apr 1;315(1):129-33. .
Chaput, JC, Ichida, JK, Szostak, JW. DNA polymerase-mediated DNA synthesis on a TNA template. J Am Chem Soc. 2003 Jan 29;125(4):856-7. .
Hanczyc MM, Szostak JW.  Replicating vesicles as models of primitive cell growth and division.  Curr Opin Chem Biol. 2004 Dec;8(6):660-4. .  
Chen, IA, Roberts, RW, Szostak, JW. The emergence of competition between model protocells.  Science 2004 Sep 3;305:1474-76. .   .  
Chen IA, Szostak JW. A kinetic study of the growth of fatty acid vesicles. Biophys J. 2004 Aug;87(2):988-98. .
Sazani PL, Larralde R, Szostak JW. A small aptamer with strong and specific recognition of the triphosphate of ATP. J Am Chem Soc. 2004 Jul 14;126(27):8370-1. . .
Chaput JC, Szostak JW. Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability. Chem Biol. 2004 Jun;11(6):865-74. .
Chen IA, Szostak JW. Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles. Proc Natl Acad Sci U S A. 2004 May 25;101(21):7965-70. .
Carothers JM, Oestreich SC, Davis JH, Szostak JW. Informational complexity and functional activity of RNA structures.  J Am Chem Soc. 2004 Apr 28;126(16):5130-7

Fujikawa SM, Chen IA, Szostak JW.  Shrink-wrap vesicles.  Langmuir. 2005 Dec 20;21(26):12124-9. .   .  
Plummer KA, Carothers JM, Yoshimura M, Szostak JW, Verdine GL.  In vitro selection of RNA aptamers against a composite small molecule-protein surface.  Nucleic Acids Res. 2005 Sep 30;33(17):5602-10. .   .  
Chen IA, Salehi-Ashtiani K, Szostak JW.  RNA catalysis in model protocell vesicles.  J Am Chem Soc. 2005 Sep 28;127(38):13213-9. .   .  
Ichida JK, Horhota A, Zou K, McLaughlin LW, Szostak JW.  High fidelity TNA synthesis by Therminator polymerase.  Nucleic Acids Res. 2005 Sep 12;33(16):5219-25. .  
Josephson K, Hartman MC, Szostak JW.  Ribosomal synthesis of unnatural peptides.  J Am Chem Soc. 2005 Aug 24;127(33):11727-35. .   .  
Horhota A, Zou K, Ichida JK, Yu B, McLaughlin LW, Szostak JW, Chaput JC.  Kinetic analysis of an efficient DNA-dependent TNA polymerase.  J Am Chem Soc. 2005 May 25;127(20):7427-34. .   .  
Shen X, Valencia CA, Szostak JW, Dong B, Liu R.  Scanning the human proteome for calmodulin-binding proteins.  Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5969-74. .   .  
Sacerdote MG, Szostak JW.  Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose.  Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6004-8. .   .  
Zou K, Horhota A, Yu B, Szostak JW, McLaughlin LW.  Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs).  Org Lett. 2005 Apr 14;7(8):1485-7. .   .     .  
Ichida JK, Zou K, Horhota A, Yu B, McLaughlin LW, Szostak JW.  An in vitro selection system for TNA.  J Am Chem Soc. 2005 Mar 9;127(9):2802-3. .   .

Horhota AT, Szostak JW, McLaughlin LW.  Glycerol nucleoside triphosphates: synthesis and polymerase substrate activities.  Org Lett. 2006 Nov 9;8(23):5345-7. .   .  
Blackburn EH, Greider CW, Szostak JW.  Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging.  Nat Med. 2006 Oct;12(10):1133-8. .  
Salehi-Ashtiani K, Luptak A, Litovchick A, Szostak JW.  A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene.  Science. 2006 Sep 22;313(5794):1788-92.
Hanczyc MM, Mansy SS, Szostak JW.  Mineral Surface Directed Membrane Assembly.  Orig Life Evol Biosph. 2007 Feb;37(1):67-82. .  
Carothers JM, Oestreich SC, Szostak JW.  Aptamers selected for higher-affinity binding are not more specific for the target ligand.  J Am Chem Soc. 2006 Jun 21;128(24):7929-37. .   .  
Seebeck FP, Szostak JW.  Ribosomal synthesis of dehydroalanine-containing peptides.  J Am Chem Soc. 2006 Jun 7;128(22):7150-1. .   .  
Hartman MC, Josephson K, Szostak JW.  Enzymatic aminoacylation of tRNA with unnatural amino acids.  Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4356-61. .   .  
Carothers JM, Davis JH, Chou JJ, Szostak JW.  Solution structure of an informationally complex high-affinity RNA aptamer to GTP.  RNA. 2006 Apr;12(4):567-79. .  
Cho GS, Szostak JW.  Directed evolution of ATP binding proteins from a zinc finger domain by using mRNA display.  Chem Biol. 2006 Feb;13(2):139-47
Hartman MC, Josephson K, Lin CW, Szostak JW. An expanded set of amino Acid analogs for the ribosomal translation of unnatural peptides. PLoS ONE. 2007 Oct 3;2(10):e972. .
Tsai CH, Chen J, Szostak JW. Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37): 14598-603. . .
Seelig B, Szostak JW. Selection and evolution of enzymes from a partially randomized non-catalytic scaffold. Nature. 2007 Aug 16;448(7155):828-31. . .
Mansy SS, Zhang J, Kummerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC. Structure and Evolutionary Analysis of a Non-biological ATP-binding Protein. J Mol Biol. 2007 Aug 10;371(2):501-13. .
Smith MD, Rosenow MA, Wang M, Allen JP, Szostak JW, Chaput JC. Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization. PLoS ONE. 2007 May 23;2:e467. .
Hazen RM, Griffin PL, Carothers JM, Szostak JW. Functional information and the emergence of biocomplexity. Proc Natl Acad Sci U S A. 2007 May 15;104 Suppl 1:8574-81. Epub 2007 May 9. .
Meena, Sam M, Pierce K, Szostak JW, McLaughlin LW.  2',3'-Dideoxy-3'-thionucleoside Triphosphates: Syntheses and Polymerase Substrate Activities.  Org Lett. 2007 Mar 15;9(6):1161-3.. .   .  

Mansy SS, Szostak JW. Thermostability of model protocell membranes. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13351-5. Epub 2008 Sep 3. .
Mansy SS, Schrum JP, Krishnamurthy M, Tobé S, Treco DA, Szostak JW. Template-directed synthesis of a genetic polymer in a model protocell. Nature. Published online 4 June 2008. .. ..
Subtelny AO, Hartman MC, Szostak JW. Ribosomal synthesis of N-methyl peptides. J Am Chem Soc. 2008 May 14;130(19):6131-6. Epub 2008 Apr 11. .
Monnard PA, Szostak JW. Metal-ion catalyzed polymerization in the eutectic phase in water-ice: A possible approach to template-directed RNA polymerization. J Inorg Biochem. 2008 May;102(5-6):1104-11. Epub 2008 Feb 1.
Bruckner RJ, Mansy SS, Ricardo A, Mahadevan L, Szostak JW. Flip-flop-induced relaxation of bending energy: implications for membrane remodeling. Biophys J. 2009 Dec 16;97(12):3113-22. .. ..
Schrum JP, Ricardo A, Krishnamurthy M, Blain JC, Szostak JW. Efficient and Rapid Template-Directed Nucleic Acid Copying Using 2'-Amino-2',3'-dideoxyribonucleoside-5'-Phosphorimidazolide Monomers. J Am Chem Soc. 2009 Oct 14;131(40):14560-70. .. ..
Mansy SS, Szostak JW. Reconstructing the Emergence of Cellular Life through the Synthesis of Model Protocells. Cold Spring Harb Symp Quant Biol. 2009 Sep 4;74:47-54. .
Ricardo A, Szostak JW. Origin of life on earth. Sci Am. 2009 Sep;301(3):54-61.
Lin S, Horning DP, Szostak JW, Chaput JC. Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy. J Phys Chem A. 2009 Sep 3;113(35):9585-7. .. ..
Budin I, Bruckner RJ, Szostak JW. Formation of protocell-like vesicles in a thermal diffusion column. J Am Chem Soc. 2009 Jul 22;131(28):9628-9.
Elenko MP, Szostak JW, van Oijen AM. Single-molecule imaging of an in vitro-evolved RNA aptamer reveals homogeneous ligand binding kinetics. J Am Chem Soc. 2009 Jul 29;131(29):9866-7. .. ..
Szostak JW. Origins of life: Systems chemistry on early Earth. Nature. 2009 May 14;459(7244):171-2. .
Zhu TF, Szostak JW. Preparation of large monodisperse vesicles. PLoS ONE. 2009;4(4):e5009. Epub 2009 Apr 6. .
Zhu TF, Szostak JW. Coupled Growth and Division of Model Protocell Membranes. J Am Chem Soc. 2009 Mar 26. [Epub ahead of print]. .. ..
Chen JJ, Tsai CH, Cai X, Horhota AT, McLaughlin LW, Szostak JW. Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates. PLoS ONE. 2009;4(3):e4949. Epub 2009 Mar 23. .
Chen JJ, Cai X, Szostak JW. N2'-->p3' phosphoramidate glycerol nucleic acid as a potential alternative genetic system. J Am Chem Soc. 2009 Feb 18;131(6):2119-21. ..

Powner MW, Sutherland JD, Szostak JW. Chemoselective multicomponent one-pot assembly of purine precursors in water. J Am Chem Soc. 2010 Nov 2;132:16677-16688. ..
Elenko MP, Szostak JW, van Oijen AM. Single-molecule binding experiments on long time scales. Rev Sci Instrum. 2010 Aug 27;81:083705. ..
Schrum JS, Zhu TF, Szostak JW. The origins of cellular life. Cold Spring Harb Perspect Biol. 2010 May 19. .. ..
Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA. Effect of Stalling after Mismatches on the Error Catastrophe in Nonenzymatic Nucleic Acid Replication. J Am Chem Soc. 2010 Apr 28;132(16):5880-5. .. ..
Budin I, Szostak JW. Expanding Roles for Diverse Physical Phenomena During the Origin of Life. Annu Rev Biophys. 2010 Jun 9;39:245-63. ..
Budin I, Szostak JW. Physical effects underlying the transition from primitive to modern cell membranes. Proc Natl Acad Sci USA. 2011 Mar 14. .. .. ..
Subtelny AO, Hartman MCT, Szostak JW. Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in vitro translation. Angew Chem Int Ed. 2011 Mar 4. .. ..

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